Integrating Exposure and Effects

Avg. Daily Intake = 1-2 pg TEQ/kg/day

WHO TDI (1998) = 1-4 pg TEQ/kg/day

Cancer (A&H)

Altered Glucose Tolerance,Insulin Metabolism, Diabetes

M-O-E =

exposure of interest

low effect level

* Dev.Eff. (Dutch, Japanese, Finnish, German Studies)

Low Dose Animal Effects1

Average Body Burden

Body Burden (ng/kg)

A = Animal H = Human

1 enzyme induction, cellular effects, viral susceptibility, oxidative damage, developmental effects, endometriosis

10-2 10-1 100 101 102 103 104

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