Cancer
IARC, NTP, EPA consensus: Known human carcinogen
(TCDD – known carcinogen; Other TEQ – likely to be carcinogenic)
(Complex environmental mixtures – Likely to be carcinogenic)
Clear evidence of animal carcinogenicity
Positive in M/F, multiple tissues, four species
Limited evidence of human carcinogenicity
Occupational studies and Seveso
(All cancers; lung; breast)
Detected in highly exposed populations
Mechanistic considerations
Cancer potency increasingly focusing on human studies