PAS Proteins

Growing Family of Regulatory Proteins

Defined by Presence of PAS (Per, Ahr, Arnt, Sim) Domain Stretch of 200-350 Amino Acids Containing Two 51-Amino Acid Repeats Which is Involved in Dimerization

Drosphila PAS Proteins:

Per

Sim

Trachealess

Tango

Vertebrate PAS Proteins:

Ahr (1,2)

Arnt (1,2,3?)

Sim1 and Sim2

Hypoxia Inducible Factor-1 Alpha (HIFA-1A)

Steroid Receptor Coactivator -1 (SRC-1)

Amplified in Breast Cancer -1 (AIB1)

Endothelial PAS Protein (EGAS)

MOPS

Neuronal PAS Domain Proteins 1,2 (NPAS 1,2)

AINT-1

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