Biochemical Effects of Dioxins

• Induction of Drug Metabolizing Genes

  • Cyp1A1/2, 1B1; GST; UDPGT; ALDH…

• Induction of Proliferation Genes

• Induction of Cytokines

  • TNF, IL-6, IL-1ß

• Induction of Oxidative Stress

• Induction of Growth factors/receptors

  • TGFs, EGFR…

• Modulation of Hormones/Receptors

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